Grapefruits and drugs: when is statistically significant clinically significant?
نویسندگان
چکیده
منابع مشابه
Grapefruits and drugs: when is statistically significant clinically significant?
Editorial Lown et al. (1) report a significant advance in describing a new mechanism by which ingested nutrients may change exposure to drug therapy. Grapefruit juice was reported to increase plasma concentrations of felodipine and nifedipine when the drug was concurrently administered with grapefruit juice (2). The potential clinical importance of such an interaction was noted when cyclosporin...
متن کاملThe Difference between "Significant" and "Not Significant" Is Not Itself Statistically Significant
It is common to summarize statistical comparisons by declarations of statistical significance or non-significance. Here we discuss one problem with such declarations, namely that changes in statistical significance are often not themselves statistically significant. By this, we are not merely making the commonplace observation that any particular threshold is arbitrary—for example, only a small...
متن کاملLow bone mineral density with tenofovir: does statistically significant mean clinically significant?
Adults with human immunodeficiency (HIV) infection appear to have a greater prevalence of low bone mineral density (BMD) and of fractures than do adults without HIV infection [1,2]. HIV infection itself may contribute to this greater prevalence. HIV induces inflammation (a known association with accelerated BMD loss), and low BMD has been reported in individuals with untreated HIV infection [1,...
متن کاملIs it a statistically significant anomaly?
Remote sensing, medical imaging, and time-lapse seismic monitoring have common challenges in change detection. In this paper we introduce a statistical procedure developed in medical imaging to determine if anomalies in time-lapse seismic data are statistically significant. Using seismic data redundancy, we construct maps of statistical variation and apply an adaptive thresholding to them. The ...
متن کاملStatistically significant sites
Most of us know less about statistics than we feel we should but, even as a scientist, it’s often not necessary to be an expert. When it comes to presenting your data, or reviewing someone else’s, however, it can help to have a ready reference at your fingertips. Before you run out and buy a textbook or ask advice from a colleague, take a look at what the web has to offer. Sites offering online...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119405